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KMID : 0811720000040000018
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Korean Journal of Physiology & Pharmacology
2000 Volume.4 No. 0 p.18 ~ p.0
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Ginsenosides Enhance Vanilloid Receptor (VR1) Channel Expressed in Xenopus oocytes : Evidence for the Involvement of Protein Kinase A
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Jung Se-Yeon
Choi Seok
Han Jeong-Eun
Kim Hyun-Ju
Kim Yoo-Jeong
Ko Yoo-Seung
Park Chul-Seung
Nah Seung-Yeol
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Abstract
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Ginsenosides or ginseng saponins are biologically active components of Panax ginseng. In previous study we demonstrated that ginsenosides attenuate capsaicin-induced pain related- behavior (Neuropharmacology 39, 2180-2184, 2000). We investigated the effects of several ginsenosides on VR1 channel activity expressed in Xenopus oocytes. We found that ginsenoside Rc showed the strongest potentiation of capsaicin-evoked currents. The effect of ginsenoside Rc was dose-dependent and blocked by competitive VR1 antagonist, capsazepine.
To investigate the possible mechanism that mediates the potentiation on capsaicin-induced currents by ginsenoside Rc, we used membrane-permeable PKA activatior, 8-Br-cAMP. Pretreatment with 8-Br-cAMP attenuated the effect of ginsenoside Rc on capsaicin-induced current. Taken together, this observation indicates that ginsenoside Rc might produce the potentiation of capsaicin-evoked currents through the cAMP-protein kinase A signaling pathway.
Source: Korean Journal of Physiology & Pharmacology.2000 Oct;4(Suppl):S14-S14
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